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Pre-workout supplements have been studied on a bunch of workout metrics, including energy, energy, and endurance, as well as time it takes to fatigue, and perception of effort-or how exhausting it looks like you’re working throughout a given process. Studies have shown that patients with migraine, including cluster headaches and menstrual migraine, usually have low ranges of magnesium, and taking supplements like magnesium oxide may be helpful. Nitric Oxide. 2019