Recent thermodynamic modelling indicates that sustaining the mind tissue ratio of O2 to CO2 (abbreviated tissue O2 /CO2 ) is essential for preserving the entropy improve obtainable from oxidative metabolism of glucose, home SPO2 device with a fall of that obtainable entropy leading to a discount of the phosphorylation potential and impairment of brain power metabolism. This offers a novel perspective for understanding physiological responses under totally different situations when it comes to preserving tissue O2 /CO2 . To enable estimation of tissue O2 /CO2 in the human mind, an in depth mathematical model of O2 and BloodVitals experience CO2 transport was developed, and H utilized to reported physiological responses to different challenges, asking: BloodVitals wearable how well is tissue O2 /CO2 preserved? Reported experimental outcomes for increased neural exercise, hypercapnia and hypoxia as a consequence of high altitude are in keeping with preserving tissue O2 /CO2 . The outcomes highlight two physiological mechanisms that management tissue O2 /CO2 : cerebral blood circulation, which modulates tissue O2