Dosage regimen#

Capsules are for oral administration. Usually prescribed to take a dose of 150 mg with an interval of 6 or 8 hours. If the patient suffers from a severe infection, the dosage can be increased to 300 or 450 mg. When prescribing the drug to children of one month of age, they are guided by the calculation of 8 or 25 mg per kg of body weight. During the day should be 3 or 4 doses.

Clindamycin for dogs and cats#

In veterinary medicine, an antibiotic clindamycin is prescribed to animals. Dogs: At 5.5 mg / kg p / o with an interval of 12 hours or 11 mg / kg with an interval of 24 hours. In cases of severe infections, it can be increased to 11 mg / kg with an interval of 12 hours. For toxoplasmosis: 25 mg / kg / day / o, in several stages. Cats: At 5.5 mg / kg p / o with an interval of 12 hours or 11 mg / kg with an interval of 24 hours. For toxoplasmosis: 25 mg / kg / day p / o, in several doses.

Pharmacokinetics#

After intravaginal clindamycin administration of 100 mg / once for 7 days, Cmax of clindamycin in blood plasma is reached after 10 hours (4-24 hours) and averages 18 ng / ml (4-47 ng / ml) on day 1 and on the 7th day - 25 ng / ml (6-61 ng / ml), while systemic absorption is about 5% (0.6-11%) of the administered dose. buy Clindamycin capsules In women with bacterial vaginosis, with a similar dosing regimen, systemic absorption undergoes about 5% of clindamycin (with a smaller spread of 2-8%), Cmax is reached 14 hours (4-24 hours) after administration and averages 13 ng / ml on the first day (6-34 ng / ml), and on the 7th day - 16 ng / ml (7-26 ng / ml). The systemic effect of clindamycin with intravaginal administration is less pronounced than when administered orally or iv. T1 / 2 is 1.5-2.6 hours. Almost no cumulation.

Mode of application#

The duration of treatment may be limited in case of side effects. The treatment of acute streptococcal tonsillitis / pharyngitis with a dose of Clindamycin-M in oral capsules is 300 mg 2 times a day for 10 days. Treatment of inflammatory diseases of the pelvic organs after parenteral administration of the drug in For 6 days, you should continue to take Clindamycin-M inside at a dose of 450-600 mg every 6:00 until the completion of the 10-14-day cycle of therapy. Cervicitis caused by Chlamydia trachomatis - 450-600 mg Clindamycin-M int. 4 times a day for 10-14 days. Prevention of endocarditis in patients with sensitivity to penicillin. Adults use 600 mg an hour before surgery or a diagnostic procedure (for example, tonsillectomy, adenoidectomy, rigid endoscope bronchoscopy, dilatation of the esophageal stricture, endoscopic retrograde cholangiopancreatography, cystoscopy) for children - 20 mg / kg at 1:00 for surgery or diagnostic procedures. Encephalitis caused by Tohorlasta in patients with AIDS - 600-1200 mg every 6:00 for 2 weeks, followed by oral administration of 300-600 mg every 6:00. The duration of treatment is usually 8-10 weeks. Oral administration of 25-75 mg of pyrimethamine per day for 8-10 weeks is necessary. When using higher doses of pyrimethamine, 10 to 20 mg of folic acid per day should be prescribed. Pneumonia caused by Rheitosustis saripia in patients with AIDS - from 300 to 450 mg every 6:00 for 21 days in combination with oral administration of 15-30 mg primaquine per day for the 21st day. Malaria - 20 mg / kg / day for at least 5 days.

Overdose#

If the dosage regimen is violated, negative reactions to the active substance of the drug increase. Symptomatic therapy is used to eliminate them.. Clindamycin does not have a neutralizing agent. Such measures as peritoneal dialysis and hemodialysis do not provide the desired effect..

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Pub: Aug 06 2020 05:12 UTC
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