TMG supplements might assist enhance heart well being, enhance athletic efficiency, and regulate insulin ranges. Taking as much as 15 grams per day may be protected, however some side effects might include diarrhea and vomiting. Trimethylglycine (TMG), also called betaine or betaine anhydrous, is a crucial anti-inflammatory and antioxidative compound that your physique can produce by itself. It’s present in foods like beetroot and can also be obtainable in supplements. TMG consists of glycine with three attached methyl groups. It’s involved in a chemical process called methylation, which is crucial for DNA production. It’s essential to note that TMG might trigger side effects, particularly if used in high doses. This text covers TMG benefits, uncomfortable side effects, dosage, and how to increase your intake with food. TMG supplements could also be related to several well being benefits. Some research exhibits that TMG might help convert homocysteine, a sort of amino acid, into another compound referred to as methionine. This is useful since high ranges of homocysteine may increase the risk of coronary heart illness.

A 2021 assessment found that taking as much as four grams (g) of TMG per day helped lower homocysteine levels with out negatively impacting other facets of coronary heart well being, like blood pressure and triglyceride ranges. That stated, other analysis discovered that TMG supplements could slightly enhance complete and LDL (bad) cholesterol ranges in the blood, both of which are threat elements for coronary heart illness. Ultimately, extra research is required on how these supplements could have an effect on coronary heart health. Many athletes use TMG supplements with the purpose of enhancing train efficiency. A 2021 study in 29 soccer players found that taking 2 g of TMG supplements for 14 weeks improved muscular energy, running velocity, and Mind Guard supplement ability to repeat sprints. Despite the potential advantages of TMG supplements for athletic performance, analysis is mixed. A 2017 review of seven studies discovered that only two research found benefits of TMG supplementation for muscle power and energy. Similarly, brain support supplement a 2020 examine found no important effects of taking TMG supplements for cross-fit coaching performance.

More studies are needed before consultants can confidently suggest TMG supplements to boost athleticism. Several studies have found that TMG supplements could improve insulin resistance, a situation that affects your body’s capacity to make use of the hormone insulin to regulate blood sugar levels. A 2017 examine in almost 2,four hundred people related a higher intake of choline and betaine with decreased insulin resistance. Plus, in a 2018 animal research, administering TMG supplements to mice on a high fat diet improved fats metabolism and decreased insulin resistance. Still, more research is required to higher understand how TMG may have an effect on insulin resistance in humans. Some analysis exhibits that TMG supplements may improve how nicely sure kinds of antidepressant medications work. Specifically, TMG has been proven to increase the consequences of S-adenosyl-methionine (Same), Mind Guard supplement a kind of remedy used to treat mild to reasonable depression. In a 2015 research together with sixty four folks with depression, those that took both Same and TMG for 12 months experienced higher enchancment in their signs than those that took Same alone.

What’s more, TMG supplements may also assist enhance signs of depression and anxiety. These situations could also be linked with elevated homocysteine ranges that TMG may help lower. These are more common if you’re taking increased doses of the supplement. In rare instances, TMG might additionally considerably improve the amount of methionine in your blood, which might cause fluid buildup around the Mind Guard supplement. If you expertise any unwanted effects from taking this supplement, discontinue use and converse with a physician. TMG supplements usually are not really useful for children and people who are pregnant or nursing, as there’s restricted analysis on their security and long-term effects on cognitive health supplement. There aren't any official dosage suggestions for TMG supplements, but most products provide 750 to 3,000 milligrams (mg) of TMG per serving. TMG is considered safe when used in doses of up to 20 g per day. Most studies on the potential benefits of TMG supplements in humans have used amounts of 500 to 9,000 mg per day, sometimes divided into several smaller doses.

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Pub: 07 Nov 2025 15:48 UTC

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