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Clinical trials that are designed to help inform practice in the real world are called pragmatic trials. They are often characterized as a focus on the practical aspects of design, including recruitment and consent, adherence and the use routinely available equipment.

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RTP

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A practical trial that employs various investigators and participants from diverse geographical locations is the Home Blood Pressure Management study (HBPM). This type of heterogeneity that is crucial for pragmatic trials to be reliable and lessen the chance of bias, is also necessary. However, too much heterogeneity can result in problems with the trial design.

Pragmatic Play is one of the major players in the live casino market, offers a variety of classic table games like Blackjack and Roulette. The live studios of the company in Romania and Malta provide customers with an authentic experience in gambling as well a full selection of virtual betting options. The company also has several games that make online gambling enjoyable and engaging. Some of these shows are hosted live and some include famous people from the field.

Mobile compatibility

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Legality


Pragmatic Play has earned a reputation for providing top-notch games and an exceptional user experience. Its software is accessible on mobile devices and in a variety of languages. Despite its relative youth it has already established itself as a premier gaming platform for casinos. Wolves is one of the latest games that is a 5-reel slot machine with a healthy RTP and stunning graphics. Other notable titles include Wolf Gold and Chilli Heat.

Pragmatic trials aim to mimic real-life situations and attain maximum external validity. They are typically commissioned by practitioners and policy makers to aid in their decision-making. They can also be used to determine the causality of an intervention with its outcomes. However, they should not be used as a substitute for explanation studies.

The concept of pragmatism is controversial, and there are questions about whether pragmatic trials should be used to replace explanation tests or if they should serve as an alternative to them. Schwartz and Lellouch1 proposed the distinction between explanation studies, which confirm a physiological hypothesis or clinical hypothesis, and pragmatic trials, which inform the practice and policy decision-making. They also suggested an approach to pragmatic trials, which they called PRECIS.2 This tool attempted to define the elements of a practical trial, including the recruitment process, the design and delivery of the intervention, as well as follow-up.

There is a positive trend in the number of pragmatic trials that have been published. A recent Medline query that used the words pragmatic and naturalistic, limited to randomised controlled trials (RCTs), returned 34 articles. These are shown in red on Figure 2. This is a sign that the health sciences community is becoming more sensitive to the issue of pragmatism. However, it is important to note that the majority of these trials were conducted in primary care settings.

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Pub: 15 Sep 2024 23:15 UTC
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