NMN Benefits

What's nicotinamide mononucleotide (NMN)?
What exactly is NMN? nicotinamide mononucleotide (NMN), a precursor for nicotinamide adenine dinucleotide (NAD+) (a key player in several cell processes and looking after our body’s status quo), is now being investigated in various clinical trials along with other research to guage its use as a possible ingredient which may help combat a variety of aging-related changes.

In 2018, together with the discharge of the 11th edition of the World Health Organization (WHO)’s ICD codes (International Classification of Diseases), age-related diseases were included being a disease state.

Classifying aging as being a disease opened the entranceway to look into on various topics related to boosting NAD+ in mammalian cells and the possible important things about slowing aging. NAD+ plays an important role in numerous activities in the body that, with aging, decline. Studies show that NAD+ levels drop almost 50% after we reach mid-life.

NMN benefits
Taken by mouth, NMN is proposed being quickly absorbed and transformed into NAD+. Preliminary studies in mice along with other lab animals, with a few recently conducted or still ongoing scientific studies, claim that enhanced degrees of NAD+ may suppress age-related inflammation in a variety of tissues, support thinking processes, production and action of insulin, and much more. Additionally, possible benefits of NMN may include:

Support of cognitive function
In a study by Shen et al., researchers demonstrated improved cognitive function and decreased depression-like behaviors in mice which are administered NMN.

Additional encouraging studies suggest that NMN administration may provide several neuroprotective effects. However, further principals are needed to see whether these effects may also be noticed in humans.

Potential role in skin aging
NMN skin benefits are currently being investigated, though studies are still within their infancy.

Inside a 2021 study by Zhou et al., researchers evaluated NMN utilization in mice. They found improvement in sun-damaged aging-related skin changes. This might initiate further development and research of novel therapeutic methods, even preventing ultraviolet sun ray-related skin damage.

In a 2022 study by Brito et al., investigators evaluated and demonstrated NMN’s role in decreasing melanin (pigment). The study’s findings suggest therapeutic potential which might benefit those that have age-related hyperpigmentation signs like dark spots later on.

Potential fertility support
Taking NMN may provide improvements in fertility in men and women.

As women age, the high quality and number of their oocytes decline. Studies in mice show that NMN administration resulted in increased ovulation, improved oocyte maturation, along with the ability to achieve fertilization.

As men age, sperm production decreases. Early mouse studies suggest that this loss of sperm production occurs secondary for the depleting numbers of NAD+ that accompany aging. This may be backed up by administering NMN which might improve sperm counts as men age.

Heart health improvements
Keeping NAD+ levels by the body processes, while aging, organic beef manage to support heart health insurance and potentially prevent some cardiovascular diseases.

Levels of NAD+ inside the cardiovascular system decrease with increasing age. Use of the NAD+ precursor, NMN, may help support healthy aging of arteries and may also reduce circulatory stiffness. Heart protective benefits may include better blood pressure control, fewer arrhythmias (abnormal heart rhythms), and in many cases improvements in overall heart function.

Metabolic health support
Decreased NAD+ levels have already been identified in animals and humans with obesity, and the ones with type 2 diabetes. Several studies, together with a mouse model by Uddin et al., advise that NMN administration not merely increases NAD+ levels but might also improve glucose clearance connected with high-fat diets resulting in obesity, diabetes, and aging. NMN may aid in diabetes regulation and obesity management down the road.

Improve sleep
NMN may join melatonin and also other supplements to further improve sleep and sleep quality, minimizing insomnia along with other sleep problems.

Inside a study by Shen et al., researchers discovered that NMN may play a role in maintaining one’s circadian rhythm.

Other animal studies also reported that providing additional NMN was consideration to enhance the objective of the GABAergic system within the body - a key player in mood disorders, neurological disease, sleep regulation, as well as other components of health. Via modifications to this system along with other pathways, findings suggest the potential use of NMN administration may play a supportive role in sleep regulation.
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Pub: 22 Feb 2024 12:58 UTC
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