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Studies designed to provide insight into clinical practice in the real world are referred to as pragmatic trials. They are often characterized as focusing on practical aspects of design that include the recruitment and consent process, as well as adherence and the use of standard equipment.
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Another example of a pragmatic trial is the Home Blood Pressure Management (HBPM) study, which used a variety of investigators and participants from various geographical areas. This type of heterogeneity is necessary for practical trials to be valid, and it also helps reduce bias in the results. Too much heterogeneity, however can result in problems with the design of the trial.
Pragmatic Play, one of the biggest players on the live casino market offers various classic table games such as Blackjack and Roulette. The live studios of Pragmatic Play's offices in Romania and Malta offer customers an authentic gaming experience as well as a broad variety of betting options via virtual. The company also hosts a variety of games which make online gambling fun and interactive. Some of these shows are broadcast live and others include famous people from the field.
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Legality
Pragmatic Play is known for its top-notch games, and for offering an exceptional user experience. The software is available on mobile devices and in multiple languages. It has earned itself the status of one of the most popular casino gaming platforms despite its relative infancy. The latest releases include Wolves 5 reel video slot with a healthful RTP and stunning graphics. Other notable games include Wolf Gold and Chilli Heat.
Pragmatic trials seek to replicate real-life settings and achieve maximum external validity. They are usually commissioned by policymakers and practitioners to inform their decisions. They also provide a useful way to identify the cause-effect relationship between the intervention and its effects. However, they should not, be used to replace explanatory studies.
The pragmatism idea is controversial and there are concerns regarding whether pragmatic trials could replace tests for explanations or if they are an addition to them. Schwartz and Lellouch1 suggested a distinction between explanatory trials, which validate the validity of a clinical or physiological hypothesis and pragmatic trials that inform policy and practice decisions. They also proposed a framework for pragmatic trials, called PRECIS.2 This tool sought to define the characteristics of a pragmatic study, including the recruitment process, the design and delivery of the intervention, and follow-up.
There is an encouraging trend in the number of pragmatic trials that have been published. A recent Medline search using the keywords naturalistic and pragmatic, limited to controlled trials randomized to control (RCTs) produced 34 articles, as shown in red in Figure 2. This indicates that the health science community is becoming more acquaint to the subject of pragmatic thinking. However, it is important to keep in mind that the majority of these studies were conducted in primary care settings.